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抑制剂/激活剂

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凋亡与自噬

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MI-2 MALT1 inhibitor

MI-2 (MALT1 inhibitor) 是不可逆的MALT1抑制剂，其IC50为 5.84 μM。

货号：
TK0229
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	1047953-91-2
生物活性	MALT1 inhibitor MI-2 is a MALT1 inhibitor (IC50=5.84 μM). MALT1 inhibitor MI-2 binds directly to MALT1, irreversibly suppresses protease function and is accompanied by NF-κB reporter activity suppression, c-REL nuclear localization inhibition, and NF-κB target gene downregulation. MALT1 inhibitor MI-2 shows nontoxic to animals.
分子式	C19H17Cl3N4O3
分子量	455.72
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : ≥ 46 mg/mL (100.94 mM)
体内研究	MALT1 inhibitor MI-2 (25 mg/kg; i.p.; daily for 14 days) profoundly suppresses the growth of both the TMD8 and HBL-1 ABC-DLBCL xenografts.
体外研究	MALT1 inhibitor MI-2 (1-1000 nM; 48 hours) selectively suppresses MALT1-dependent DLBCL cell lines, and the GI50 in HBL-1, TMD8, OCI-Ly3, and OCI-Ly10 cells is 0.2, 0.5, 0.4, and 0.4 µM, respectively.MALT1 inhibitor MI-2 (62-1000 nM; 24 hours) causes a dose-dependent decrease in MALT1-mediated cleavage.
纯度及产品资料	98%

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