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抑制剂/激活剂

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凋亡与自噬

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Nicotinamide 烟酰胺; Niacinamide; Nicotinic acid amide

Nicotinamide 是一种 B3 维生素，通过促进 NAD+ 氧化还原稳态和提供 NAD+ 作为催化非氧化还原反应的一类酶的底物，在细胞生理学中发挥重要作用。烟酰胺是 SIRT1 抑制剂。

货号：
TK0226
规格：

500mg

1g

5g
价格：
￥0.00

产品参数

CAS No.	98-92-0
生物活性	Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD redox homeostasis and providing NAD as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.
分子式	C6H6N2O
分子量	122.12
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, protect from light
溶解性数据	DMSO : ≥ 100 mg/mL (818.87 mM) H2O : ≥ 50 mg/mL (409.43 mM)
体内研究	Normal and streptozotocin-nicotinamide induced adult male diabetic rats receive quercetin (10, 25 and 50 mg/kg/bw) orally, and cause significant decrease in FBG and cardiac injury marker levels with increased in insulin levels. Nicotinamide improves maternal hypertension, proteinuria, and glomerular endotheliosis in RUPP mice. Moreover, nicotinamide prolongs pregnancies, and improves survival and growth of the embryos in RUPP PE mice.
体外研究	Pretreatment with the poly (ADP-ribose) polymerase (PARP) inhibitor nicotinamide is able to prevent HCN2 cell death. When nicotinamide is added prior to t-BuOOH, it is able to prevent neuronal cell death and inhibit apoptosis. Nicotinamide-pretreated neurons have higher expression levels of inhibitors of apoptosis (IAP) genes. Nicotinamide inhibits vasoconstriction by ET. Nicotinamide also alleviates oxidative stress, which exacerbates PE and FGR.
文献	•Autophagy. 2020 Oct;16(10):1823-1837. •Nat Commun. 2021 Sep 20;12(1):5548. •Nat Commun. 2021 Jul 9;12(1):4227. •EMBO J. 2020 Sep 15;39(18):e104365. •Theranostics. 2019 Apr 13;9(9):2424-2438. •Oncogene. 2020 Mar;39(11):2437-2449. •Aging Cell. 2021 Oct 3;e13491. •Cell Death Dis. 2021 Sep 23;12(10):865. •Hum Reprod. 2020 Mar 27;35(3):494-503. •Hum Reprod. 2019 Jul 8;34(7):1186-1194. •Oxid Med Cell Longev. 2021 Jan 19;2021:6610543. •J Mol Med (Berl). 2019 Aug;97(8):1183-1193. •Am J Physiol Heart Circ Physiol. 2021 Jun 18. •Theriogenology. 2020 Dec;158:233-238. •bioRxiv. 2020 Mar. •Patent. US20180263995A1.
纯度及产品资料	98%

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