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抑制剂/激活剂

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凋亡与自噬

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SEA0400

SEA0400 是一种选择性的 Na+-Ca2+ exchanger (NCX) 的强效抑制剂，可抑制神经细胞、星形胶质细胞和小胶质细胞中Na+依赖性的Ca2+吸收，对应的IC50值分别为33 nM、5.0 nM和8.3 nM。SEA0400 可防止硝普钠 (SNP) 提高 ERK 和 p38 MAPK 的磷酸化和通过细胞外Ca2+依赖的方式增强reactive oxygen species (ROS) 的产生。

货号：
TK0221
规格：

1mg

2mg
价格：
￥0.00

产品参数

CAS No.	223104-29-8
生物活性	SEA0400 is a novel and selective inhibitor of the Na-Ca exchanger (NCX), inhibiting Na-dependent Ca uptake in cultured neurons, astrocytes, and microglia with IC50s of from 5 to 33 nM.
分子式	C21H19F2NO3
分子量	371.38
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : ≥ 32 mg/mL (86.17 mM)
体内研究	SEA0400 (3 mg/kg + 3 mg/kg/h for 2 h, i.v.) attenuates the infarct volume in the cerebral cortex and striatum, does not affect the mean the regional cortical blood flow in anesthetized rats. SEA0400 protects against the dopaminergic neurotoxicity (determined by dopamine levels in the midbrain and striatum, tyrosine hydroxylase immunoreactivity in the substantia nigra and striatum, striatal dopamine release, and motor deficits) in MPTP-treated C57BL/6J mice.
体外研究	SEA0400 inhibits Na-dependent Ca uptake in cultured neurons, astrocytes, and microglia. IC50 values of SEA0400 are 33 nM (neurons), 5.0 nM (astrocytes), and 8.3 nM (microglia). SEA0400 prevents sodium nitroprusside (SNP) to increase ERK and p38 MAPK phosphorylation, and production of reactive oxygen species (ROS) in an extracellular Ca-dependent manner.
文献	•Autophagy. 2021 Feb 25;1-15. •J Clin Invest. 2016 Jan;126(1):112-22. •JCI Insight. 2019 Apr 25;5(11):e128765. •Cell Calcium. 2016 Jul;60(1):25-31. •Cells. 2019 Dec 31;9(1):102. •J Physiol. 2015 Aug 1;593(15):3333-50. •J Physiol. 2015 Mar 15;593(6):1459-77. •J Physiol. 2014 Nov 15;592(Pt 22):4969-93. •Cell Signal. 2017 May 20;37:12-30. •Am J Physiol Heart Circ Physiol. 2016 Dec 1;311(6):H1352-H1359. •Pflugers Arch. 2015 Oct;467(10):2151-63. •Brain Res. 2016 Aug 1;1644:249-57. •Biochem Biophys Rep. 2017 Jan 11;9:245-256. •JACC Basic Transl Sci. 2016 Jun;1(4):251-266.
纯度及产品资料	98%

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