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Nigericin sodium salt

Nigericin sodium salt 日利亚菌素钠盐

Nigericin sodium salt是从Streptomyces hygroscopicus衍生的抗生素，通过充当H+，K+和Pb2+的离子载体起作用。Nigericin可以激活NLRP3炎性体以诱导促炎和免疫刺激过程。

货号：
TK0214
规格：

1mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	28643-80-3
生物活性	Nigericin sodium salt is an antibiotic from Streptomyces hygroscopicus that works by acting as an H, K, and Pb ionophore, a NLRP3 activator.
分子式	C40H68O11
分子量	746.94
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶解性数据	Ethanol : ≥ 50 mg/mL (66.94 mM)
体内研究	Ngericin (4 mg/kg, i.p.) significantly reduces tumor growth and acts synergistically with the chemotherapeutic agent DDP, as shown by the tumor volumes. Nigericin markedly decreases Bmi-1 in vivo. Overexpression of Bmi-1 partially restores CSC content and metastatic ability of NPC cells under Nigericin treatment. The downregulation of Bmi-1 may be involved in the inhibitory effect of Nigericin on CSCs in NPC.
体外研究	Nigericin (0.1 µM) decreases inhibits proliferation and clonogenicity of H460 lung cancer cells in a dose dependent manner. Nigericin inhibits migration and invasion of H460 lung cancer cells. Nigericin (0.1-10 nM) has apparently a dual effect on cell volume, that is a shrinking effect at lower Nigericin concentrations and a swelling effect at higher concentrations. Nigericin (0.1-1 nM) significantly decreases cytosolic pH (pHi), and slightly increases the pHi at 5 and 10 nM. Nigericin exhibits higher toxicity on S18 cells than S26 cells, with IC50 of 2.03±0.55 μM and 4.77±2.35 μM, respectively. Nigericin can selectively kill cancer stem cells in NPC in vitro. Nigericin dramatically reduces the migration ability of S18 and HONE-1 cells. Nigericin exhibits gteat toxicity for the HT29 and SW116 cell line with IC50 of 12.92±0.25 μmol and 15.86±0.18 μmol. Nigericin also shows a decreased ability to form colonies under anchorage-independent conditions in a standard soft agar assay.
文献	•Cell Metab. 2020 May 5;31(5):892-908.e11. •Cell Death Differ. 2021 Sep 11. •Cell Rep. 2019 May. •Crit Care. 2021 Oct 12;25(1):356. •Cell Death Dis. 2021 Dec 14;12(12):1159. •Cell Death Dis. 2020 Feb 18;11(2):132. •J Neuroinflammation. 2021 Jun 24;18(1):142. •Front Immunol. 2021 Jul 7;12:688674. •Sensor Actuat B-Chem. 297 (2019) 126801. •Ther Adv Med Oncol. 2021 Jan 21. •Cell Biol Toxicol. 2021 Oct 12. •Acta Pharmacol Sin. 2021 Sep 24;1-8. •Phytother Res. 2021 Mar 3. •Aging (Albany NY). 2021 Aug 25;13(16):20534-20551. •Front Microbiol. 2020 Apr 30;11:790. •Mol Neurobiol. 2021 Sep 25. •iScience. 21 September 2021. •J Cell Mol Med. 2021 Nov;25(21):10268-10278. •J Cell Mol Med. 2020 Jul;24(14):8078-8090. •CNS Neurosci Ther. 2021 Dec 23. •Cell Death Discov. 2021 Feb 10;7(1):31. •J Biol Chem. 2021 Dec 22;101532. •Life Sci. 2021 Jul 21;282:119814. •Int Immunopharmacol. 2021 Jan 7;92:107352. •Am J Chin Med. 2020;48(7):1693-1713. •J Funct Foods. December 2020, 104274. •Mol Immunol. 2020 Apr 13;122:28-37. •J Ethnopharmacol. 2021 Sep 30;114694. •Int J Mol Med. 2021 Dec;48(6):219. •Inflammation. 2021 Jan 6. •Int J Med Sci. 2020 Jun 29;17(11):1652-1664. •Biochem Biophys Res Commun. 2020 May 7;525(3):759-766. •Appl Microbiol Biotechnol. 2017 May;101(10):4201-4213. •Exp Ther Med. 2021 Oct;22(4):1046. •Brain Behav. 2020 Jun;10(6):e01627. •Research Square Preprint. 2021 Jul. •Oncotarget. 2018 Jan 13;9(13):10868-10879.
纯度及产品资料	≥98%

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