>>

>>

抑制剂/激活剂

>>

凋亡与自噬

>>

EIPA

EIPA (L593754; MH 12-43)是巨胞饮作用(macropinocytosis) 和钠氢交换剂(sodium-hydrogen exchanger, NHE) （IC50=0.033 μg/mL）的抑制剂。EIPA阻断了Na(+)/H(+)交换剂(Na(+)/H(+) exchanger)的活性，Na(+)/H(+) exchanger是一种涉及所有巨胞吞作用的质膜蛋白。

货号：
TK0213
规格：

1mg

5mg

10mg

50mg
价格：
￥0.00

产品参数

CAS No.	1154-25-2
生物活性	EIPA (L593754) is a TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also inhibits Na/H-exchanger (NHE) and macropinocytosis.
分子式	C11H18ClN7O
分子量	299.76
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : 140 mg/mL (467.04 mM; Need ultrasonic)
体外研究	In the presence of 100 μM EIPA, 10 μM benzamil, and 10 μM phenamil, Ca uptake decreases from 79±9 to 46±4 (58% remaining), 27±4 (34%), 29±5 (37%), and 38±4 (48%) pmol/oocyte/30 min (n=6, P=0.008), respectively. It is found that EIPA, benzamil, and phenamil rapidly and reversibly block Ca-activated TRPP3 channel activation at -50 mV, with IC50s of 143±8 (n=36), 10.5±2.2 (n=28), 1.1±0.3 (n=30), and 0.14±0.04 μM (n=25), respectively. The number of autophagic vacuoles increases dramatically in the HAE and HPE groups after EIPA treatment compare with the HAN and HPN groups. EIPA regulates the initiation and maturation of the autophagy associated with amino acids in IEC-18 cells. In addition, the uptake of cinnamoylphenazine (CA-PZ) and neutral red (NR) is inhibited by EIPA.
纯度及产品资料	98%

推荐产品