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抑制剂/激活剂

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凋亡与自噬

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BAPTA-AM

BAPTA-AM 是选择透过性膜calcium螯合剂。

货号：
TK0209
规格：

1mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	126150-97-8
生物活性	BAPTA-AM is a well-known membrane permeable Ca chelator. BAPTA-AM inhibits hERG channels, hKv1.3 and hKv1.5 channels in HEK 293 cells with IC50s of 1.3 μM, 1.45 μM and 1.23 μM, respectively.
分子式	C34H40N2O18
分子量	764.68
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 50 mg/mL (65.39 mM; Need ultrasonic) H2O : < 0.1 mg/mL (ultrasonic) (insoluble)
体外研究	BAPTA-AM inhibits neuronal Ca-activated K channel currents, and up-regulates the decreased cardiac sodium current (INa) density by chelating intracellular Ca. BAPTA-AM (BAPTA/AM), an intracellular calcium chelator, induces delayed necrosis by lipoxygenase-mediated free radicals in mouse cortical cultures. BAPTA-AM prevents free radical-mediated toxicity promote apoptosis in non-neuronal cells and produce a beneficial effect in neuronal cells by protecting neurons from ischemic damage. In addition, it has been suggested that BAPTA-AM induces a late, but not early, increase of intracellular calcium in I-IL-60 neoplastic cells. Mixed cortical cell cultures (DIV 13-16) exposed to 10 μM BAPTA-AM for 24- or 48-hr show moderate (45-70%) neuronal injury as evaluated by increased LDH release into the bathing medium after 24-48-hr. Exposure of cortical cultures to 3-10 μM BAPTA-AM for 48-hr evoke dose-dependent neuronal damage.
文献	•Nat Immunol. 2019 Apr;20(4):433-446. •Autophagy. 2021 Apr;17(4):925-947. •Nat Commun. 2021 May 18;12(1):2915. •Clin Transl Med. 2020 Oct;10(6):e205. •Cancer Lett. 2021 Jul 3;S0304-3835(21)00325-6. •Cell Death Dis. 2021 Dec 14;12(12):1159. •Cell Death Dis. 2021 Oct 13;12(10):942. •Part Fibre Toxicol. 2018 Oct 19;15(1):39. •Mucosal Immunol. 2020 Nov;13(6):931-945. •J Cell Physiol. 2021 Jan 11. •Am J Physiol Lung Cell Mol Physiol. 2021 Oct 27. •Life Sci. 2019 Jul 1;228:85-97. •Exp Cell Res. 2019 Jun 15;379(2):191-202. •Biosci Rep. 2019 Jul 2;39(7):BSR20190516. •RSC Adv. 2019, 2019, 9, 25107-25118. •Virology. 2020 Jan 2;539:38-48. •Endocr J. 2021 Oct 29. •Research Square Preprint. 2020 Jun. •Oncotarget. 2016 Feb 9;7(6):6711-26.
纯度及产品资料	98%

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