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抑制剂/激活剂

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凋亡与自噬

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AP20187 B/B Homodimerizer

AP20187 (B/B Homodimerizer, HY-13992) 是一种二聚化的化学诱导剂，可激活 FKBP-Casp8。

货号：
TK0195
规格：

1mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	195514-80-8
生物活性	AP20187 (B/B Homodimerizer) is a cell-permeable ligand used to dimerize FK506-binding protein (FKBP) fusion proteins and initiate biological signaling cascades and gene expression or disrupt protein-protein interactions.
分子式	C82H107N5O20
分子量	1482.75
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	Ethanol : 150 mg/mL (101.16 mM; Need ultrasonic)
体内研究	Real-time PCR analysis shows that AP20187 (B/B Homodimerizer) (0.5 mg/kg, 2 mg/kg, or 5 mg/kg) treatment significantly increases the levels of CHOP mRNA in the CNS of PLP/Fv2E-PERK mice at PID12. AP20187 treatment significantly alleviates EAE-induced myelin damage in these mice. AP20187 (B/B Homodimerizer) treatment significantly reduces the number of degenerating axons and increases the density of axons in the demyelinating lesions in the lumbar spinal cord of PLP/Fv2E-PERK mice.
体外研究	When LNCaP cells are treated with AP20187 (B/B Homodimerizer) (100 nM), ro-iCaspase-9 levels are significantly reduced, and the smaller processed active caspase-9 becomes apparent.
文献	•Circulation. 2016 Jul 5;134(1):61-72. •Cell Metab. 2019 May 7;29(5):1061-1077.e8. •Cell Stem Cell. 2020 Jun 4;26(6):845-861.e12. •Cell Death Differ. 2021 Jan;28(1):251-266. •Nat Commun. 2019 May 7;10(1):2091. •EMBO J. 2021 Mar 25;e106048. •Cell Discov. 2021 Jun 1;7(1):41. •Aging Cell. 2019 Jun;18(3):e12950. •Cell Death Dis. 2021 Oct 23;12(11):994. •Cell Death Dis. 2018 Apr 27;9(5):500. •FASEB J. 2018 Jun 18:fj201800548. •Methods. 2018 May 1;140-141:40-51. •PLoS One. 2021 Mar 29;16(3):e0248996. •Microbiol Immunol. 2020 Feb;64(2):143-152. •Harvard University. Graduate School of Arts & Sciences. 2016 Apr.
纯度及产品资料	98%

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