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抑制剂/激活剂

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凋亡与自噬

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Etoposide 依托泊苷; VP-16; VP-16-213

Etoposide是一种鬼臼毒素的半合成衍生物，通过抑制topoisomerase II 活性而抑制DNA合成，从而增强 DNA 的双链和单链裂解，并可逆地抑制topoisomerase II结合的修复。Etoposide可诱导自噬、线粒体自噬和细胞凋亡。

货号：
TK0194
规格：

10mg

25mg

50mg

100mg

200mg
价格：
￥0.00

产品参数

CAS No.	33419-42-0
生物活性	Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy.
分子式	C29H32O13
分子量	588.56
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : ≥ 39 mg/mL (66.26 mM)
体内研究	Etoposide (50 μM) and Anti-Human VEGF-treated hypoxic cells injected intravenously into immunodeficient mice reveals a reduced capacity to induce lung colonies, which also appear with a longer latency period. Etoposide (10 mg/kg/day, i.v.) with NSC 109724 and NSC 241240, reduces the tumor volume in the hepatoblastoma cell injected NMRI nude mice.
体外研究	Etoposide is capable of causing cytotoxicity on pancreatic β-cells by inducing apoptosis through the JNK/ERK-mediated GSK-3 downstream-triggered mitochondria-dependent signaling pathway in RIN-m5F cells. Etoposide and Anti-Human VEGF significantly abolish P1 sphere-forming ability, an effect associated with apoptosis of this subset of cells. Etoposide phosphate (0-1μM; 72 hours) inhibits HCT116 FBXW, FBXW and p53 as a dose-dependent manner, exhibits IC50s of 0.945 μM; 0.375 μM; and 1.437 μM, respectively. Etoposide (25 μM; 6 hours) delays p53 recover in FBXW7-deficient cells. In addition, FBXW7 expression is disappeared in FBXW7 cells.
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纯度及产品资料	98%

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