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抑制剂/激活剂

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凋亡与自噬

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740 Y-P 740YPDGFR; PDGFR 740Y-P

740 Y-P (PDGFR 740Y-P, 740YPDGFR)是具有细胞可透过性的PI3K磷酸肽激活剂。

货号：
TK0188
规格：

1mg
价格：
￥0.00

产品参数

CAS No.	1236188-16-1
生物活性	740 Y-P (740YPDGFR; PDGFR 740Y-P) is a potent and cell-permeable PI3K activator. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85 but fails to bind GST alone.
分子式	C141H222N43O39PS3
分子量	2272.61
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : 25 mg/mL (7.64 mM; Need ultrasonic) H2O : 2 mg/mL (0.61 mM; Need ultrasonic)
体内研究	740 Y-P is not only internalised in living cells but can also interact with p85 in vivo. 740 Y-P (intraperitoneal injection; 10 mg/kg; 6 weeks) decreases the degree of ROS levels in Aβ(25-32) treated hippocampal tissues and increases the extent of AKT and PI3K phosphorylation in alzheimer’s disease (AD) rat model.
体外研究	740 Y-P (50 μg/mL; 48 hours) specificly stimulates mitogenesis in medium is better than EGF or FGF at stimulating entry into S-phase, it shows the percentage of cells in S-phase for 48.3% in C2 cells. Additionally, LY294002 or Wortmannin potently inhibits the mitogenic response stimulated by the peptide. 740 Y-P (1 μg/mL) stimulates mitogenesis at the lowest concentration tested. The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%), and in the former instance a maximal response observed at 50 μg/mL. 740Y-P to stimulate mitogenesis is highly specific and not a general feature of a cell permeable SH2 domain binding peptides. 740 Y-P (30 μM; 24 hours) remarkably inhibits the level of LC3-II/LC3-I in GO-induced PC12 cells.
文献	暂无相关参考文献
纯度及产品资料	95%

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