>>

>>

抑制剂/激活剂

>>

凋亡与自噬

>>

Z-LEHD-FMK

Z-LEHD-FMK 是一种选择性和不可逆的 caspase-9 抑制剂，可防止致命的再灌注损伤并减弱细胞凋亡。Z-LEHD-FMK 在大鼠脊髓损伤模型中也表现出神经保护作用。

货号：
TK0183
规格：

1mg
价格：
￥0.00

产品参数

CAS No.	210345-04-3
生物活性	Z-LEHD-FMK is a selective and irreversible inhibitor of caspase-9, protects against lethal reperfusion injury and attenuates apoptosis. Z-LEHD-FMK exhibits the neuroprotective effect in a rat model of spinal cord trauma.
分子式	C32H43FN6O10
分子量	690.72
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : 100 mg/mL (144.78 mM; Need ultrasonic and warming)
体内研究	Z-LEHD-FMK (0.8 μmol/kg; i.v. for 7 d) protects neurons, glia, myelin, axons, and intracellular organelles in spinal cord injury (SCI) rats.
体外研究	Z-LEHD-FMK (20 μM; pretreated for 30 min) completely protects HCT116 and 293 cells from TRAIL-induced toxicity. Z-LEHD-FMK (20 μM ; 6 h) protects normal human hepatocytes from TRAIL-induced apoptosis.
文献	暂无相关参考文献
纯度及产品资料	≥98%

推荐产品