>>

>>

抑制剂/激活剂

>>

凋亡与自噬

>>

Z-DEVD-FMK

Z-DEVD-FMK (Caspase-3 Inhibitor)是一种特异性，不可逆的Caspase-3抑制剂，也能有效抑制caspase-6， caspase-7， caspase-8和caspase-10。

货号：
TK0159
规格：

1mg
价格：
￥0.00

产品参数

CAS No.	210344-95-9
生物活性	Z-DEVD-FMK is a specific and irreversible caspase-3 inhibitor with an IC50 of 18 μM.
分子式	C30H41FN4O12
分子量	668.66
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : ≥ 33.33 mg/mL (49.85 mM)
体内研究	Early Z-DEVD-FMK (160 ng) treatment improves motor and cognitive function after traumatic CNS injury induced by severe controlled cortical impact (CCI) in the mouse. Treatment with Z-DEVD-FMK (160 ng) significantly improves neurological outcome when compared with traumatized animals treated with DMSO vehicle (p<0.01).
体外研究	N27 cells are exposed to MPP in the absence or presence of 50 μM Z-DIPD-FMK or 100 μM Z-DEVD-FMK or 50 μM Z-LEHD-FMK and then caspase-9 and caspase-3 enzymatic activities are determined by enzymatic assay at 12 and 24 h following exposure, respectively. Exposure to 300 μM MPP for 24 h in N27 cells results in an approximately 2.5-fold increase in caspase-3 enzyme activity. MPP-induced increases in caspase-3 enzyme activity are significantly blocked by 50 μM Z-DIPD-FMK, 100 μM Z-DEVD-FMK, and 50 μM Z-LEHD-FMK.
文献	暂无相关参考文献
纯度及产品资料	≥98%

推荐产品