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抑制剂/激活剂

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凋亡与自噬

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MG-132

MG132 ((S,R,S)-(-)-MG-132, Z-Leu-D-Leu-Leu-al)是一种有效的蛋白酶体(ChTL, TL和PGPH)抑制剂。MG132对calpain也有抑制作用(IC50=1.2 μM)。MG-132可用于诱导帕金森病动物疾病模型。

货号：
TK0135
规格：

1mg

2mg

5mg

10mg
价格：
￥0.00

产品参数

CAS No.	1211877-36-9
生物活性	(R)-MG-132 ((S,R,S)-(-)-MG-132) is the enantiomer of MG-132. (R)-MG-132 is a proteasome inhibitor with weaker cell cytotoxicity than MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.
分子式	C26H41N3O5
分子量	475.62
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder, -20°C ,3 years
溶解性数据	DMSO : 100 mg/mL (210.25 mM; Need ultrasonic)
体外研究	(R)-MG-132, the stereoisomer of MG-132, is studied as a potential inhibitor of chymotrypsin-like, trypsin-like, and peptidylglutamyl peptide hydrolyzing activities of proteasome.MG-132 and (R)-MG-132 are investigated for inhibition of ChTL, trypsin-like (TL) and peptidylglutamyl peptide hydrolyzing (PGPH) activities of purified 20S proteasomes isolated from human erythrocytes. For MG-132, the IC50s of 0.89 μM, 104.43 μM, and 5.7 μM for ChTL, TL, and PGPH, respectively. For (R)-MG-132, the IC50s of 0.22 μM, 34.4 μM, and 2.95 μM for ChTL, TL, and PGPH, respectively.
纯度及产品资料	98%

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