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抑制剂/激活剂

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凋亡与自噬

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WP1066

WP1066 是一种新颖的 JAK2 和 STAT3 抑制剂，对 STAT5 和 ERK1/2 也起作用，但对 JAK1 和 JAK3 没有影响。

货号：
TK0118
规格：

1mg

5mg

10mg

25mg
价格：
￥0.00

产品参数

CAS No.	857064-38-1
生物活性	WP1066 is an inhibitor of JAK2 and STAT3, and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3.
分子式	C17H14BrN3O
分子量	356.22
储存条件	Powder -20℃ 3 years
溶解性数据	DMSO : ≥ 44 mg/mL (123.52 mM) Ethanol : 16.67 mg/mL (46.80 mM; Need ultrasonic)
体内研究	WP1066 (30 mg/kg, o.g.) exerts an additive effect to CTX inhibition of the p-STAT3 pathway within the tumor microenvironment.
体外研究	WP1066 markedly inhibits the growth of HEL cells in a dose-dependent manner. The IC50 value for inhibition of the proliferation of HEL cells is 2.3 μM. WP1066 inhibits the growth of human HEL cells carrying the JAK2 V617F mutant isoform. Blockade of p-STAT3 with WP1066 enhances the cytotoxic effects of CTX on the tumor. The IC50 doses of WP1066 for B16 cells is 2.43 µM (0.865 µg/mL). WP1066 inhibits AML blast colony-forming cell proliferation, suppresses normal BM progenitor proliferation at increased concentrations, and inhibits AML colony-forming cell proliferation.
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纯度及产品资料	98%

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