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抑制剂/激活剂

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凋亡与自噬

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Ionomycin MCH 32

Ionomycin (SQ23377) 是一种有效的选择性钙离子载体，也是由Streptomyces conglobatus产生的抗生素。它诱导蛋白激酶C (PKC)的激活并促进细胞凋亡。

货号：
TK0115
规格：

1mg

5mg
价格：
￥0.00

产品参数

CAS No.	56092-81-0
生物活性	Oligomycin A (MCH 32), created by Streptomyces, acts as a mitochondrial F0F1-ATPase inhibitor, with a Ki of 1 μM; Oligomycin A shows anti-fungal activity.
分子式	C45H74O11
分子量	791.06
运输条件	Room temperature in continental US; may vary elsewhere.
储存条件	Powder -20°C 3 years
溶解性数据	DMSO : 100 mg/mL (126.41 mM; Need ultrasonic)
体外研究	Oligomycin A is a mitochondrial F0F1-ATPase inhibitor with a Ki of 1 μM. Oligomycin A shows cytotoxic to the NCI-60 cell lines, with GI50 of 10 nM. Oligomycin A also inhibits the activity of Triton X-100-solubilized ATPase with a Ki of 0.1 μM. Furthermore, Oligomycin A has anti-fungal activity. Oligomycin A (2.4 µM) inhibits the ability of spermatozoa to achieve feasible in vitro capacitation (IVC), and also suppresses progesterone-induced in vitro acrosome exocytosis (IVAE) as well as the concomitant peaks of O2 consumption and ATP levels.
文献	•Cell Res. 2021 Sep;31(9):980-997. •Clin Transl Med. 2021 Apr;11(4):e395. •Cell Rep. 2021 Sep 21;36(12):109739. •PLoS Biol. 2021 Apr 27;19(4):e3001197. •J Leukoc Biol. 2021 Dec 20. •Sci Rep. 2021 Dec 14;11(1):23977. •Nutr Cancer. 2020;72(4):696-707. •SSRN. 15 Sep 2021 . •Cell Physiol Biochem. 2018;48(6):2318-2336.
纯度及产品资料	95%

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