Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) 抑制肝脏中的线粒体呼吸链，导致 AMPK 活化，增强胰岛素敏感性，可用于 2 型糖尿病的研究。Metformin hydrochloride 可以透过血脑屏障，诱导自噬 (autophagy)。
| CAS No. | 1115-70-4 |
| 生物活性 | Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits the mitochondrial respiratory chain in the liver, leading to activation of AMPK, enhancing insulin sensitivity for type 2 diabetes research. Metformin hydrochloride triggers autophagy. |
| 分子式 | C4H11N5 |
| 分子量 | 165.62 |
| 储存条件 | Powder -20℃ 3 years |
| 溶解性数据 | H2O : 250 mg/mL (1509.48 mM; Need ultrasonic) DMSO : ≥ 1.7 mg/mL (10.26 mM) |
| 体内研究 | Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride; 100 mg/kg, p.o.) alone, and metformin (25, 50, 100 mg/kg) with NSC 37745 groups attenuates myocyte necrosis through histopathological analysis. |
| 体外研究 | Metformin hydrochloride (1,1-Dimethylbiguanide hydrochloride) inhibits proliferation of ESCs in a concentration-dependent manner. The IC50 is 2.45 mM for A-ESCs and 7.87 mM for N-ESCs. Metformin shows pronounced effects on activation of AMPK signaling in A-ESCs from secretory phase than in cells from proliferative phase. Metformin hydrochloride (0-500 μM) decreases glycogen synthesis in a dose-dependent manner with an IC50 value of 196.5 μM in cultured rat hepatocytes. Metformin hydrochloride shows cell viability and cytotoxic effects on PC-3 cells with IC50 of 5 mM. |
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| 纯度及产品资料 | 98% |
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