Doxorubicin (DOX) HCl是一种抗生素类试剂，可抑制人类DNA topoisomerase II，IC50 为 2.67 μM。Doxorubicin 可降低 AMPK的基础磷酸化。Doxorubicin 可应用于HIV感染病人的联合治疗，但是在免疫治疗中有将HBV重活化的风险。此产品溶解于PBS溶液可能会析出。推荐使用纯水配置母液，纯水或生理盐水稀释为工作液。Doxorubicin (Adriamycin) HCl可用于诱导肾病动物疾病模型。
| CAS No. | 25316-40-9 |
| 生物活性 | Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human DNA topoisomerase I and topoisomerase II inhibitor with IC50s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy. |
| 分子式 | C27H30ClNO11 |
| 分子量 | 579.98 |
| 储存条件 | Powder -20℃ 3 years |
| 溶解性数据 | DMSO : 35.71 mg/mL (61.57 mM; ultrasonic and warming and heat to 60°C) H2O : 20 mg/mL (34.48 mM; Need ultrasonic) |
| 体内研究 | Treatment with Doxorubicin (2 mg/kg) or Zoledronic acid (100 μg/kg) alone does not statistically significantly decrease final tumor volume compared with saline. Mice treated with Doxorubicin plus Zoledronic acid have statistically significantly smaller final tumor volumes than those treated with Doxorubicin alone. |
| 体外研究 | Doxorubicin hydrochloride (1-8 µM; 24 and 48 hours) decreases the viability of MCF-10F, MCF-7 and MDA-MB-231 cells in a time- and dose-dependent manner. Doxorubicin hydrochloride (1 μM; 3 and 24 hours) results in Hct-116 human colon carcinoma cells reduction in G0/G1 phase and accumulation in G2 phase. Doxorubicin hydrochloride (1 μM for MCF-10F and MDA-MB-231 cells, 4 μM for MCF-7 cells; 48 hours) induces apoptosis by upregulating Bax, caspase-8 and caspase-3 and downregulation of Bcl-2 protein expression. |
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| 纯度及产品资料 | 98% |
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