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TLR4 Monoclonal antibody

TLR4 Monoclonal antibody

货号：
AM20133
规格：

20ul

50ul

100ul
价格：
￥0.00

产品说明书前往锐竞购买

产品参数

别名	toll like receptor 4, TOLL, hToll, CD284, ARMD10
产品类型	Monoclonal
基因名称	toll-like receptor 4
经测试应用	WB, IHC
宿主	Mouse
种属反应性	Human, Mouse, Rat
免疫原	A synthesized peptide derived from human TLR4
理论分子量	96 kDa
实际分子量	80-96kDa
Gene ID(NCBI)	7099
GeneBank Accession Number	BC117422
UNIPROT	O00206
形式	Liquid
保存条件	Store at -20℃. Stable for one year after shipment. Aliquoting is unnecessary for -20℃ storage.
推荐稀释比例	1:1000-1:4000
背景信息	The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene.

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